|
KMID : 1039520200240040191
|
|
Journal of Audiology & Otology
2020 Volume.24 No. 4 p.191 ~ p.197
|
|
|
Comparison of Autophagy mRNA Expression between Chronic Otitis Media With and Without Cholesteatoma
|
|
Jung Jun-Yang
Jung Su-Young
Kim Myung-Gu
Kim Young-Il
Kim Sang-Hoon
Yeo Seung-Geun
|
|
|
Abstract
|
|
|
Background and Objectives: Autophagy is known to be associated with pathogen infection. However, the expression of autophagy-related proteins has not been studied in chronic otitis media without cholesteatoma (COM) or with cholesteatoma (CholeOM). This study aimed to determine whether there is a difference between COM and CholeOM in autophagy-related gene mRNA expression.
Subjects and Methods: For 47 patients with chronic otitis media, the inflammatory tissues were classified into granulation tissue (COM) or cholesteatoma (CholeOM) according to biopsy results.
Results: PI3K mRNA expression (COM vs. CholeOM, mean±SD, 0.009±0.010 vs. 0.003±0.004; p=0.004) was lower, whereas Beclin-1 mRNA expression (0.089±0.107 vs. 0.176±0.163; p=0.034) was higher in the CholeOM group. Expression of PI3K mRNA in the CholeOM group was lower than that in the COM subgroups with presence of bacteria (0.022±0.019 vs. 0.001±0.001; p=0.001), otorrhea (0.049±0.068 vs. 0.003±0.004; p=0.004), and hearing loss over 40 dB (0.083±0.130 vs. 0.003±0.004; p=0.005).
Conclusions: The data suggested that different autophagy proteins play important roles in chronic otitis media according to the presence or absence of cholesteatoma.
|
|
|
KEYWORD
|
|
|
Autophagy, Otitis media, Cholesteatoma
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|